Synthetic Nondegradable Gingival Reinforcement Patch
About Gingival Recession
Gingival recession, also known as receding gums, is the exposure of the roots of teeth caused by a loss of gum tissue and/or retraction of the gingival margin from the crown of the teeth. Gum recession is a common problem in adults over the age of 40, but it may occur as early as the age of 10.
There are many known causes for gingival recession. By far the most common are gum disease and overaggressive brushing. Due to the incremental nature of the condition, receding gums may remain unnoticed until symptoms appear, such as tooth mobility and dentin hypersensitivity (over-sensitive teeth).
Gum recession can be addressed by a variety of gum grafting "periodontal plastic surgery" procedures. These are mainly performed due to aesthetic reasons or to address hypersensitivity and may involve repositioning of adjacent gum tissue to cover the recession (called a pedicle graft) or use of a free graft of gingival or connective tissue from the roof of the mouth (called a free gingival graft). Alternatively, a material called acellular dermal matrix (processed donated human skin allograft) may be used instead of tissue from the patient's own palate. Success is usually determined by two measures: Complete Root Coverage (CRC), which is the rate of teeth treated in which the tooth root is completely covered by gingival tissue and Mean Root Coverage (MRC), which is the level of coverage.
CorNeat gPatch Advantages
It is poised to provide a high rate of complete and mean root coverage
It cannot carry disease
Easier to transport
Ease of handling
The CorNeat gPatch presents a new approach to gingival recession surgery, which does not rely on autografts or allografts/xenografts that degrade over time. The CorNeat gPatch is 100% synthetic and nondegradable and therefore provides permanent reinforcement for gum tissue, ensuring effectiveness over time. The CorNeat gPatch microstructure, which imitates the Extracellular Matrix (ECM), renders it both durable and flexible. It can be easily cut and sutured to a certain place and does not rip or tear when manipulated. Once covered, it acts as a permanent “scaffold,” stimulating cellular infiltration and colonization.
Inlet (regulating pressure)
Provides deterministic IOP: the inlet mimics the trabecular meshwork's adaptive pressure regulation mechanism so that as the intraocular pressure increases the outflow through the inlet increases and keeps the actual pressure constant
Prolonged patency: the eShunt's outlet is uniquely positioned deep within the orbit where there is mostly fat and minimal fibrotic ability
Tube (ocular Integration)
The eShunt's shaft biologically integrates with neighboring tissue by leveraging porous, biocompatible and non-degradable polymers in a configuration that mimics the Extra Cellular Matrix (ECM)
The CorNeat eShunt has successfully passed initial bench tests and animal trials demonstrating seamless integration and the ability to reduce and regulate intraocular pressure. The R&D and preclinical phases are expected to take 12-15 months.
CorNeat eShunt device marketing is pending regulatory approvals.