CorNeat KPro  

A revolutionary innovation in corneal replacement therapy

About Corneal Blindness 

Diseases affecting the cornea are a major cause of blindness worldwide. According to the World Health Organization, approximately 2 million new cases of corneal blindness are reported each year. Over 30 million people in the world are legally blind in one or both eyes from corneal injury and disease, while many more suffer from degraded visual acuity. A recent study published in JAMA Ophthalmology* assessed the shortage of corneas at one available cornea for 70 needed.

Several attempts to develop an artificial cornea have failed in creating robust, scalable and reliable solutions. As such, there exists an unmet need for an efficient, long-lasting and affordable solution to corneal pathology, injury and blindness, which would alleviate this suffering and disability and enable patients to fully exploit their vision potential. 

*Gain P, Jullienne R, He Z, et al. Global Survey of Corneal Transplantation and Eye Banking. JAMA Ophthalmol. 2016;134(2):167–173. doi:10.1001/jamaophthalmol.2015.4776

Eye contact1_Shutterstock.jpg

Global Demand

World map showing the supply and demand of corneal transplantation in 148 Countries


"Our survey globally quantified the considerable shortage of corneal graft tissue, with only one cornea available for 70 needed. Efforts to encourage cornea donation must continue in all countries, but it is also essential to develop alternative and/or complementary solutions, such as corneal bio-engineering."*


*Gain P, Jullienne R, He Z, et al. Global Survey of Corneal Transplantation and Eye Banking. JAMA Ophthalmol. 2016;134(2):167–173. doi:10.1001/jamaophthalmol.2015.4776


CorNeat KPro Advantages 

CorNeat KPro is superior to keratoplasty and current keratoprosthetics in the following aspects

Optical Performance

Replicating optimal corneal optics


Wide field of view


Simplifying the surgical procedure via direct visualization while

enabling future procedures in a similar fashion


Healing & Retention

Device integrates to the eye wall using nano-fabric that imitates the native ECM


Fast to heal


Progressive integration


Straight forward post-operation recovery


Relatively simple, 45-minute operation


Affordable price


No time constraints placed on scheduling of the implantation


No need for tissue


 Cannot carry any infectious agent including COVID-19

CorNeat KPro

The CorNeat KPro is an artificial cornea, keratoprosthesis (KPro), which provides a long-lasting medical solution for corneal blindness, pathology and injury. The CorNeat KPro implant is a patented synthetic cornea utilizing advanced cell technology to integrate artificial optics within resident ocular tissue. It is produced using nanoscale chemical engineering, which stimulates cellular growth.

Current biological solutions (keratoplasty), and previous KPros, are either sutured to, or attempt integration with, the native corneal tissue – a tissue that lacks blood vessels and heals very poorly. The CorNeat KPro integrates underneath the conjunctiva, the white part of the eye, a site rich with fibroblasts, which heals quickly and vigorously. 


The CorNeat KPro is combined with a novel and relatively simple surgical procedure to provide an efficient, therapeutic, and affordable remedy for millions of people with cornea-related visual impairments and is far superior to any available alternative. 


Features and Surgical Procedure 

The CorNeat KPro implantation procedure is relatively short and simple when compared to other KPros and even keratoplasty (a corneal transplant). Unlike current procedures requiring delicate suturing of donor tissue to the patient’s native cornea, a process which can only be performed by very skilled and thoroughly trained specialists, the CorNeat KPro snaps into the patient’s trephined cornea and is then sutured to the eye using three non-degradable sutures. The process itself minimizes the time the eye is trephined and open (also known as “open sky”) to less than one minute – significantly reducing the risks involved.

The CorNeat KPro lens is designed to enable post-operative ophthalmic examinations and subsequent anterior and posterior segment surgeries (i.e. cataract and retinal surgeries). This is enabled by four openings or “ports,” located on the rim of the lens, placed over the limbus.


Being 100% synthetic, sterile and composed of inert materials, the device is not expected to bear infectious agents or cause excessive inflammation. This will result in improved quality of life and more effective patient care.




Failed keratoplasty 

Corneal indications not suitable for keratoplasty, such as: 

  • Herpes keratitis

  • Corneal degenerations

  • ICE syndrome

  • Aniridia

  • SJS

  • OCP

  • Alkali burns

  • Vascularized cornea


Regulatory Path

CorNeat Vision designed, produced and tested several versions of the CorNeat KPro, successfully completing the pre-clinical phase which included a groundbreaking 6-months-long study, successfully proving its safety.


The CorNeat KPro is planned to begin clinical trials during the second half of 2020, toward FDA (510K) clearance (USA) and CE marking (Europe).

Given the apparent superiority over donor tissue, we are planning to conduct a  study with broader indications including as first line treatment, which will enable us to expand the device's indications for use. At present, the device is expected to achieve the initial clearance in 2022.

In China, where there are over 5 million patients waiting for keratoplasty and only a few thousand transplantations a year, we are planning a study which will facilitate turning the CorNeat KPro into a primary solution for corneal blindness. The study is planned to start in 2021 and will include 60-70 local patients toward the NMPA (previously CFDA) approval (China).


The plans above are subject to regulatory approvals and requirements.

For more information:


Product Animation 

 CorNeat KPro
CorNeat KPro

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Would a person with severe dry eye be a candidate for the CorNeat KPro implantation?

Initially we will treat patients with some tear production. With the accumulation of experience, we will collect the necessary evidence to encourage surgeons to tackle the most challenging and arid ophthalmic patients, suffering from alkali chemical burn, Stevens-Johnson Syndrome or ocular cicatricial pemphigus.

Would a person with Stevens-Johnson Syndrome be a candidate for the CorNeat KPro implantation?

See previous answer.

Would a person with herpes keratitis be a candidate for the CorNeat KPro implantation?

Yes, we believe that Herpes patients stand to gain a valid therapeutic modality, which is currently missing in the battery of clinical ophthalmic solutions.

Would a person with a scarred cornea be a candidate for the CorNeat KPro implantation?

Scarred, opaque and/or vascularized corneas are excellent candidates for the CorNeat KPro.

Would a person who had laser correction surgery be a candidate for the CorNeat KPro implantation?

Yes, laser correction does not interfere with the CorNeat KPro implantation procedure.

Would a person who had a corneal transplantation (one or more) which was/were rejected be a candidate for the CorNeat KPro implantation?

Yes, patients with failed corneal grafts are our ideal candidates for implantation.

What are the differences between the CorNeat KPro and the Boston KPro?

The Boston KPro utilizes a donor cornea to attach the synthetic lens to the eye. The bond between the optic (artificial lens) and the donor cornea erodes with time, creating hypotonicity and a port of entry for bacteria, usually leading to loss of the eye. In most areas of the world, tissue is scarce and procedural knowledge of corneal transplantation limits its scalability. The CorNeat KPro is completely synthetic and in animal implantations the bond between the device and the tissue has been shown to be strong and long-lasting. The CorNeat KPro is an off-the-shelf device, and therefore scalable. The Boston KPro provides a narrow field of view both for the patient and the physician. This limits the ability of the practitioner to follow up on the eye’s health and intervene in time. The CorNeat KPro has a wide field of view similar to the native cornea. This will allow regular and thorough follow-up, provide the patient with real-life optics and maintain an aesthetic appearance. The Boston KPro is a temporary solution, which needs to be replaced once every few years, when all goes well, or it fatally damages the eye's visual potential through a variety of complications. The CorNeat KPro is engineered to be a permanent solution with robust integration into the eye’s tissues. Following implantation of the Boston KPro, access to the internal ocular compartments is blocked thus surgical procedures cannot be carried out. The CorNeat KPro is engineered to ease anterior chamber access following implantation. The bays on the optic’s rim enable anterior chamber access following implantation and will stay accessible throughout the patient’s life. Posterior chamber access is readily available through the device’s integrating element, which should stay accessible throughout life as well.


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Ra'anana, Israel

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