Glaucoma is a disease of the eye's optic nerve that impacts the lives of about 80 million people globally. Damage to the optic nerve takes place when fluid pressure builds up in the front of the eye (the anterior chamber). Excess fluid, called the aqueous humor, increases the eye's intraocular pressure which in turn damages the optic nerve. This damage leads to partial yet gradual loss of the visual field, usually starting from the periphery but eventually leading to the loss of central vision and blindness.
Current treatment modalities aim to control intraocular pressure by either reducing the aqueous humor production or increasing its drainage/absorption. These include drops, laser surgery, MIGS (Minimally Invasive Glaucoma Shunts), incisional surgery and glaucoma drainage devices. All these treatment options lose their effectiveness within a limited timeframe.
CorNeat eShunt Advantages
The CorNeat eShunt's outlet is placed in the intraconal space, a space with minimal fibrotic potential
Scarring is the major cause of failure of any surgical approach to glaucoma and until the arrival of the CorNeat eShunt no attempt was made to drain the excess fluid to this deep orbital space
Covered with a synthetic, nondegradable, ECM-like material that stimulates cellular growth - integrating the tube into the subconjunctival space
Eliminates the need for using a tissue patch
Shortens the procedure and secures the device to the eye wall permanently
Engineered to imitate the human physiologic, drainage pathways
Reacts to the changes in intraocular pressure and drains only the amount needed
Ease of Implantation
Implantation procedure can be completed in under 15 minutes
Does not require additional, processed, tissue
Will probably not require an introducer or a dedicated tool
The CorNeat eShunt is determined to revolutionize the treatment of glaucoma. It is designed to regulate the intraocular pressure and addresses the shortcomings of existing solutions. Using advanced materials, the CorNeat eShunt inlet, which is placed in the anterior chamber angle, mimics the trabecular meshwork’s function in terms of flow resistance. The CorNeat eShunt outlet is uniquely positioned in the intraconal space, an area that does not scar and clog and can absorb the drained aqueous humor. The CorNeat eShunt tube, which is covered by a synthetic ECM layer, seamlessly integrates with the ocular tissue as it traverses the subconjunctival space, significantly shortening the surgical procedure.
The CorNeat eShunt has successfully passed initial bench tests and animal trials demonstrating seamless integration and the ability to reduce and regulate intraocular pressure. The R&D and preclinical phases are expected to take 12-15 months.
CorNeat eShunt device marketing is pending regulatory approvals.